Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping
Émilie Montastier, Run Zhou Ye, Christophe Noll, Lucie Bouffard, Mélanie Fortin, Frédérique Frisch, Serge Phoenix, Brigitte Guérin, Éric Turcotte, Gary F. Lewis, André C. Carpentier
Abstract
We found higher adipose tissue dietary fatty acid trapping, limiting spillover to lean organs, that in part offsets the increase in appearance rate of palmitate from intracellular lipolysis in prediabetes. These results point to the adaptive nature of adipose tissue trapping and dietary fatty acid spillover as a protective mechanism against excess obesity-related palmitate appearance rate from intracellular adipose tissue lipolysis.
Topics & Concepts
Adipose tissueLipolysisPostprandialInternal medicineEndocrinologyFatty acidWhite adipose tissueChemistryPrediabetesIntracellularBiochemistryBiologyType 2 diabetesDiabetes mellitusMedicineAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity