Bioinspired ginsenoside Rg3 PLGA nanoparticles coated with tumor-derived microvesicles to improve chemotherapy efficacy and alleviate toxicity
Shulei Zhang, Zheng Bo, Yiqi Wei, Yuhao Liu, Lan Yang, Yujiao Qiu, Jing Su, Mingfeng Qiu
Abstract
dendritic cells, along with a reduction in phagocytic activity and acid phosphatase levels. When combined with DOX, the synergistic effect of Rg3-PLGA@TMVs significantly inhibits 4T1 tumor growth and fosters the development of antitumor immunity in tumor-bearing mice. Most notably, this delivery system effectively mitigates the toxic side effects of DOX, particularly those affecting the heart. Overall, Rg3-PLGA@TMVs provide a novel strategy to enhance the efficacy of DOX while simultaneously mitigating its associated toxicities and demonstrate promising potential for the combined chemo-immunotherapy of breast cancer.
Topics & Concepts
MicrovesiclesChemotherapyPLGAMalignancyToxicityRadiation therapyMedicineBreast cancerPharmacologyChemistryCancerNanoparticleInternal medicineNanotechnologyMaterials sciencemicroRNABiochemistryGeneExtracellular vesicles in diseaseInflammatory Biomarkers in Disease PrognosisReproductive System and Pregnancy