Functional studies of GWAS variants are gaining momentum
Florence Lichou, Gosia Trynka
Abstract
Rapidly advancing genomic technologies and cross-disciplinary partnerships are accelerating the biological and clinical interpretation of genome-wide association studies, with some therapies developed based on these findings already being tested in clinical trials. The next decade promises further progress in understanding the function of genetic variants.
Topics & Concepts
Genome-wide association studyComputational biologyFunction (biology)Clinical trialGenetic variantsBiologyBioinformaticsMedicineData scienceGeneticsComputer scienceSingle-nucleotide polymorphismGeneGenotypeGenomics and Rare DiseasesSingle-cell and spatial transcriptomicsGenetics and Neurodevelopmental Disorders