Sensitive imaging of tumors using a nitroreductase-activated fluorescence probe in the NIR-II window
Xiaofan Zhang, Xiaohua Li, Wen Shi, Huimin Ma
Abstract
A nitroreductase (NTR)-activated NIR-II fluorescence probe for tumor imaging is reported. The probe can emit fluorescence in the range of 900-1300 nm, and target hypoxic tumors with NTR overexpression, thus allowing for accurate delineation of tumor margins through deep penetration.
Topics & Concepts
NitroreductaseFluorescenceChemistryFluorescence-lifetime imaging microscopyWindow (computing)OpticsBiochemistryProdrugComputer sciencePhysicsOperating systemNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesLuminescence and Fluorescent Materials