Natural products targeting human lactate dehydrogenases for cancer therapy: A mini review
Huankai Yao, Feng Yang, Yan Li
Abstract
Reprogramming cancer metabolism has become the hallmark of cancer progression. As the key enzyme catalyzing the conversion of pyruvate to lactate in aerobic glycolysis of cancer cells, human lactate dehydrogenase (LDH) has been a promising target in the discovery of anticancer agents. Natural products are important sources of new drugs. Up to now, some natural compounds have been reported with the activity to target LDH. To give more information on the development of LDH inhibitors and application of natural products, herein, we reviewed the natural compounds with inhibition of LDH from diverse structures and discussed the future direction of the discovery of natural LDH inhibitors for cancer therapy.
Topics & Concepts
Lactate dehydrogenaseCancerGlycolysisCancer therapyBiochemistryEnzymeCancer cellChemistryReprogrammingAnaerobic glycolysisPharmacologyCancer researchBiologyCellGeneticsCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchEnzyme function and inhibition