Palladium-Catalyzed Three-Component Cross-Coupling of Conjugated Dienes with Indoles Using Ethynylbenziodazolones as Electrophilic Alkynylating Reagents
Jie Huang, Ling‐Ling Chen, Zhi‐Min Chen
Abstract
A palladium-catalyzed regioselective 1,2-alkynyl-carbonalization of conjugated dienes with ethynylbenziodazolone (EBZ) and indoles has been developed for the first time. Various molecules containing alkenyl, alkynyl, and indole groups were readily obtained. Moreover, the resulting products can be applied to various derivatizations. This protocol uses EBZ as an electrophilic alkynylating reagent, avoiding the byproduct of dimerization of alkynes.
Topics & Concepts
ChemistryRegioselectivityElectrophileConjugated systemPalladiumReagentIndole testCatalysisCombinatorial chemistryMoleculeOrganic chemistryComponent (thermodynamics)ThermodynamicsPhysicsPolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions