Kukoamine A Protects against NMDA-Induced Neurotoxicity Accompanied with Down-Regulation of GluN2B-Containing NMDA Receptors and Phosphorylation of PI3K/Akt/GSK-3β Signaling Pathway in Cultured Primary Cortical Neurons
Yang Yue, Lingyue Gao, Yixuan Niu, Xiang Li, Wenwu Liu, Xiaowen Jiang, Yaqian Liu, Qingchun Zhao
Topics & Concepts
NeuroprotectionExcitotoxicityNMDA receptorNeurotoxicityWortmanninProtein kinase BPI3K/AKT/mTOR pathwayPharmacologyChemistryCell biologyGlutamate receptorPhosphorylationBiologySignal transductionReceptorBiochemistryToxicityOrganic chemistryNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms