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Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Marie Wong, Chelsea Mayoh, Loretta M. S. Lau, Dong-Anh Khuong-Quang, Mark Pinese, Amit Kumar, Paulette Barahona, Emilie Wilkie, Patricia A. Sullivan, Rachel Bowen-James, Mustafa Syed, Iñigo Martincorena, Federico Abascal, Alexandra Sherstyuk, Noemi Fuentes-Bolanos, Jonathan Baber, Peter Priestley, M. Emmy M. Dolman, Emmy D.G. Fleuren, Marie-Emilie Gauthier, Emily Mould, Velimir Gayevskiy, Andrew J. Gifford, Dylan Grebert‐Wade, Patrick Strong, Elodie Manouvrier, Meera Warby, David M. Thomas, Judy Kirk, Kathy Tucker, Tracey O’Brien, Frank Alvaro, Geoffrey McCowage, Luciano Dalla‐Pozza, Nicholas G. Gottardo, Heather Tapp, Paul Wood, Seong Lin Khaw, Jordan R. Hansford, Andrew S. Moore, Murray D. Norris, Toby N. Trahair, Richard B. Lock, Vanessa Tyrrell, Michelle Haber, Glenn M. Marshall, David S. Ziegler, Paul G. Ekert, Mark J. Cowley

2020Nature Medicine405 citationsDOIOpen Access PDF

Topics & Concepts

GermlineTranscriptomeGenomePrecision medicineMedicineDNA methylationBioinformaticsCancerGermline mutationSomatic cellOncologyBiologyInternal medicineGeneGeneticsMutationGene expressionNeuroblastoma Research and TreatmentsGlioma Diagnosis and TreatmentCancer Genomics and Diagnostics
Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer | Litcius