Biosynthesis of Calipyridone A Represents a Fungal 2-Pyridone Formation without Ring Expansion in <i>Aspergillus californicus</i>
Yaojie Guo, Fabiano Jares Contesini, Xinhui Wang, Simone Ghidinelli, Ditte S. Tornby, Thomas Emil Andersen, Uffe Hasbro Mortensen, Thomas Ostenfeld Larsen
Abstract
via nucleophilic attack of the iminol nitrogen to the carbonyl carbon is different from the biosynthesis of other fungal 2-pyridone products through P450-catalyzed tetramic acid ring expansions. In addition, two biogenetic intermediates, calipyridones B and C, showed modest inhibition effects on the plaque-forming ability of SARS-CoV-2.
Topics & Concepts
ChemistryRing (chemistry)BiosynthesisAspergillusStereochemistryBiochemistryMicrobiologyOrganic chemistryEnzymeBiologyMicrobial Natural Products and BiosynthesisFungal Biology and ApplicationsPlant tissue culture and regeneration