Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently
Zimo Yang, Yonghui Sun, Zhihao Ni, Celi Yang, Yan Tong, Yujie Liu, Haitao Li, Yu Rao
Topics & Concepts
BiologyBruton's tyrosine kinaseGLUEComputational biologyGeneticsReceptorMaterials scienceTyrosine kinaseComposite materialProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis