TLR4 enhances TGF-β signaling and hepatic fibrosis
Ekihiro Seki, Samuele De Minicis, Christoph H. Österreicher, Johannes Kluwe, Yosuke Osawa, David A. Brenner, Robert F. Schwabe
Topics & Concepts
Hepatic stellate cellTLR4Hepatic fibrosisDownregulation and upregulationProinflammatory cytokineChemokineCell biologyKupffer cellToll-like receptorTLR2Signal transductionLipopolysaccharideTransforming growth factor betaFibrosisChemistryReceptorBiologyInternal medicineInflammationImmunologyEndocrinologyMedicineBiochemistryInnate immune systemGeneLiver physiology and pathologyClinical Nutrition and GastroenterologyLiver Disease Diagnosis and Treatment