α-Carbonyl sulfoxonium ylides in transition metal-catalyzed C–H activation: a safe carbene precursor and a weak directing group
Anurag Singh, Shreemoyee Kumar, Chandra M. R. Volla
Abstract
gas. However, compared with diazo compounds, sulfoxonium ylides are generally crystalline solids, more stable, widely used in industrial scales, and easier/safer to prepare. Therefore, recent years have witnessed an upsurge in employing α-carbonyl sulfoxonium ylides as an alternative carbene surrogate in transition metal-catalyzed C-H activation. Unlike diazo compounds, α-carbonyl sulfoxonium ylides contain inherent potential to serve as a coupling partner as well as a weak directing group. This review will summarize the progress made in both categories of reactions.
Topics & Concepts
DiazoCarbeneTransition metalCatalysisExothermic reactionChemistryHeteroatomCyclopropanationCombinatorial chemistryPhotochemistryMedicinal chemistryOrganic chemistryRing (chemistry)Catalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions