Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy
Aravind Madhavan, K. B. Arun, Akhil Raj Pushparajan, Madhuri S Balaji, Ramakrishnan Ajay Kumar
Abstract
Drug-resistant TB is a serious challenge to TB control programs all over the world which calls for finding alternative therapeutic methods. Host-directed therapy is gaining significant momentum in treating infectious diseases. We propose that ZBTB25 is a potential target for host-directed treatment of TB.
Topics & Concepts
RepressorCorepressorHDAC1Gene silencingTranscription (linguistics)BiologyMycobacterium tuberculosisAutophagyTranscriptional regulationGeneTranscription factorHistoneCell biologyTuberculosisGeneticsHistone deacetylaseMedicineLinguisticsApoptosisPathologyPhilosophyTuberculosis Research and EpidemiologyEpigenetics and DNA MethylationBiochemical and Molecular Research