A multifunctional protein pre-coated metal–organic framework for targeted delivery with deep tissue penetration
Jun Yong Oh, Min‐Seok Seu, Ayan Kumar Barui, Hae Won Ok, Dohyun Kim, Eunshil Choi, Junmo Seong, Myoung Soo Lah, Ja‐Hyoung Ryu
Abstract
imaging and evaluation of tumor inhibition following injection of IR-780 loaded Col-Afb-M808 in 4T1tumor-bearing nude mice. This study offers key insights into the regulation of the multifunctional protein-adhesive surface of MOF particles, paving the way for the designing even more effective targeted drug delivery systems with nano-sized MOF particles.
Topics & Concepts
Extracellular matrixMaterials scienceNanotechnologyPenetration (warfare)Conjugated systemSupramolecular chemistryMetal-organic frameworkMetalTumor microenvironmentChemistryTumor cellsCancer researchPolymerBiochemistryOrganic chemistryMedicineMoleculeComposite materialAdsorptionMetallurgyOperations researchEngineeringMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsRNA Interference and Gene Delivery