Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology
Martha Sahylí Ortega Pijeira, Herlys Viltres, Ján Kozempel, Michal Sakmár, Martin Vlk, Derya İlem‐Özdemir, Meliha Ekinci, Seshasai Srinivasan, Amin Reza Rajabzadeh, Eduardo Ricci‐Júnior, Luciana Magalhães Rebêlo Alencar, Mohammed Al‐Qahtani, Ralph Santos‐Oliveira
Abstract
BACKGROUND: Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. Nanomedicine, a term for the application of nanotechnology in medical and health fields, uses nanoparticles for several applications such as imaging, diagnostic, targeted cancer therapy, drug and gene delivery, tissue engineering, and theranostics. RESULTS: Here, we overview the current state-of-the-art of radiolabeled nanoparticles for molecular imaging and radionuclide therapy. Nanostructured radiopharmaceuticals of technetium-99m, copper-64, lutetium-177, and radium-223 are discussed within the scope of this review article. CONCLUSION: Nanoradiopharmaceuticals may lead to better development of theranostics inspired by ingenious delivery and imaging systems. Cancer nano-theranostics have the potential to lead the way to more specific and individualized cancer treatment.