Mechanochemical activation of disulfide-based multifunctional polymers for theranostic drug release
Zhiyuan Shi, Qingchuan Song, Robert Göstl, Andreas Herrmann
Abstract
-butyl-4-hydroxy-1,8-naphthalimide and umbelliferone as fluorescent reporter molecules to accompany the release of camptothecin and gemcitabine as clinically employed anticancer agents. The generality of this approach paves the way for the theranostic release of a variety of probes and drugs by ultrasound.
Topics & Concepts
Disulfide bondPolymerDrugCombinatorial chemistryMaterials scienceChemistryNanotechnologyChemical engineeringOrganic chemistryPharmacologyEngineeringMedicineBiochemistryPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics researchBiochemical effects in animals