Multifunctionally disordered TiO<sub>2</sub> nanoneedles prevent periprosthetic infection and enhance osteointegration by killing bacteria and modulating the osteoimmune microenvironment
Yangmengfan Chen, Liqiang Zhou, Ming Guan, Shue Jin, Peng Tan, Xiaoxue Fu, Zongke Zhou
Abstract
The bionic insect wing AgNPs-PDA@TNN coating exhibited bactericidal property, immunomodulatory ability, and enhanced osteointegration. Thus, this multidimensional bionic implant surface holds promise as a novel strategy to prevent periprosthetic infection.
Topics & Concepts
OsseointegrationPeriprostheticMicrobiologyBacteriaChemistryInflammationNanotechnologyMaterials scienceMedicineBiologyImmunologyImplantArthroplastySurgeryGeneticsBone Tissue Engineering MaterialsGraphene and Nanomaterials ApplicationsOrthopaedic implants and arthroplasty