β-actin contributes to open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming
Mohamed Al‐Sayegh, Syed Raza Mahmood, S. B. Abul Khair, Xin Xie, Mei El Gindi, Tayne C. Kim, A. Almansoori, Piergiorgio Percipalle
Abstract
We demonstrate that nuclear actin regulates heterochromatin during adipogenesis by mediating Brg1 deposition at specific adipogenic gene loci to ensure binding of the transcription factor CEBPB. This mechanism contributes to CEBPA gene expression during adipogenic transcriptional reprograming.
Topics & Concepts
CEBPABiologyAdipogenesisTranscription factorChromatinHeterochromatinCell biologyGene expressionActinRegulation of gene expressionGeneGeneticsGenomics and Chromatin DynamicsNuclear Structure and FunctionVirus-based gene therapy research