Regio- and enantioselective formation of tetrazole-bearing quaternary stereocenters <i>via</i> palladium-catalyzed allylic amination
Shahid Khan, Yu Wang, Meina Zhang, Shahida Perveen, Junjie Zhang, Ajmal Khan
Abstract
A general and efficient method via catalysis by readily available Pd(0)/DACH-naphthyl catalyst under mild conditions, unlocks a new platform that permits the synthesis of elusive quaternary N 2 -allylic tetrazoles, even in the context of late-stage functionalization.
Topics & Concepts
StereocenterChemistryAllylic rearrangementAminationEnantioselective synthesisCatalysisPalladiumTetrazoleCombinatorial chemistryContext (archaeology)Organic chemistryPaleontologyBiologySynthesis of Tetrazole DerivativesChemical Synthesis and AnalysisMulticomponent Synthesis of Heterocycles