Hybrid spherical nucleotide nanoparticles can enhance the synergistic anti-tumor effect of CTLA-4 and PD-1 blockades
Jing Zhang, Dan Liu, Jiale Liu, Yanfeng Han, Haiyan Xu, Xigang Leng, Deling Kong, Lanxia Liu
Abstract
hSNPs elicit robust anti-tumor immune responses through targeted evading the immune suppressive function of Tregs and TIM3<sup>+</sup> exhausted-like CD8<sup>+</sup> T cells while promoting CD4<sup>+</sup> T cells, especially ICOS<sup>+</sup> Th1-like CD4<sup>+</sup> T cells, and CD8<sup>+</sup> effector T cells in a nonredundant fashion.
Topics & Concepts
EffectorImmune systemChemistryCytotoxic T cellCD8Function (biology)Molecular biologyCell biologyBiologyBiochemistryImmunologyIn vitroCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune Cell Function and Interaction