Quaternized antimicrobial peptide mimics based on harmane as potent anti-MRSA agents by multi-target mechanism covering cell wall, cell membrane and intracellular targets
Jinyi Liu, Yidan Cao, Chenggong Xu, Runchu Li, Yingyan Xiong, Wei Yi, Xianghui Meng, Wenjia Dan, Chunbo Lu, Jiangkun Dai
Topics & Concepts
ChemistryIntracellularAntimicrobialPeptideCell membraneMechanism (biology)CellMembraneCombinatorial chemistryBiochemistryBiophysicsOrganic chemistryBiologyPhilosophyEpistemologySynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsToxin Mechanisms and Immunotoxins