Chalcone-inspired indole, carbazole, and phenothiazine hybrids as potent aldose reductase inhibitors with selective anticancer potential: Rational design, synthesis, and multi-level characterization
Özcan Güleç, Hatice Esra Duran, Mustafa Arslan, Gizem Yıldıztekin, Abdulilah Ece, Cüneyt Türkeş
Topics & Concepts
ChemistryChalconeAldose reductaseRational designPhenothiazineStereochemistryADMELead compoundCombinatorial chemistryBiochemistryEnzymeIn vitroPharmacologyNanotechnologyMedicineMaterials scienceAldose Reductase and TaurineEnzyme function and inhibitionSynthesis and Biological Evaluation