Design, synthesis and anticancer activity of naphthoquinone derivatives
Xiaobao Shen, Yang Wang, Xuanzhen Han, Liang-Quan Sheng, Fufang Wu, Xinhua Liu
Abstract
had been investigated by AnnexinV/PI staining, immunofluorescence, Western blot assay and molecular docking. The results indicated that this compound might induce cell apoptosis and cell autophagy through regulating the PI3K signal pathway.
Topics & Concepts
PharmacophoreNaphthoquinoneChemistryApoptosisWestern blotMoietyStereochemistryDocking (animal)Autophagy1,4-NaphthoquinoneIC50BiochemistryCombinatorial chemistryIn vitroGeneNursingMedicineOrganic chemistryBioactive Compounds and Antitumor AgentsSynthesis of Indole DerivativesCalcium signaling and nucleotide metabolism