Electron donor–acceptor complex of aryl sulfonium salt enabling hydrogen/halogen atom transfer: C(sp<sup>3</sup>)–H alkylation of glycine derivatives and late-stage modification of peptides
Xiaobo Dang, Chenyang Zhang, Jinlong Shang, Xinyu Song, Chun‐Lin Wang, Rupeng Qi, Zhaoqing Xu, Qiao Chen, Mengran Wang, Chao Wang
Abstract
a radical-radical coupling strategy, enabled by a sequential intermolecular charge transfer and atom transfer steps, for synthesizing unnatural amino acids and modifying peptides.
Topics & Concepts
SulfoniumChemistryHalogenArylSalt (chemistry)AlkylationHydrogen atomGlycineAcceptorPhotochemistryMedicinal chemistryOrganic chemistryAmino acidCatalysisPhysicsAlkylBiochemistryCondensed matter physicsChemical Reactions and IsotopesChemical Synthesis and AnalysisFluorine in Organic Chemistry