A novel GPER antagonist protects against the formation of estrogen-induced cholesterol gallstones in female mice
Chelsea DeLeon, Helen H. Wang, Joseph Gunn, McKenna Wilhelm, Aidan Cole, Stacy D. Arnett, David Q.‐H. Wang, Christopher K. Arnatt
Abstract
) mice treated with 6 μg/day 17β-estradiol and fed the lithogenic diet for 8 weeks. In conclusion, CIMBA treatment protects against the formation of estrogen-induced cholesterol gallstones by inhibiting the GPER signaling pathway in female mice. CIMBA may thus be a new agent for effectively treating cholesterol gallstone disease in women.
Topics & Concepts
GPERGallstonesEstrogenInternal medicineEndocrinologyEstrogen receptorOvariectomized ratCholesterolOxysterolChemistryMedicineBreast cancerCancerEstrogen and related hormone effectsFerrocene Chemistry and ApplicationsInflammatory mediators and NSAID effects