LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Rosalie T. Zwiggelaar, Håvard T. Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, N. Parmar, Emilie Kvaløy, Roos R. Spanjers, Kamran Nazmi, Morten Beck Rye, Finn Drabløs, C.H. Arrowsmith, John Arne Dahl, Kim B. Jensen, Toshiro Sato, Menno J. Oudhoff
Abstract
-deficient epithelium has superior regenerative capacities after irradiation injury. In summary, we found an important regulator of neonatal intestinal development and identified a druggable target to reprogram intestinal epithelium toward a reparative state.
Topics & Concepts
Intestinal epitheliumEpitheliumGeneBiologyGeneticsCell biologyComputational biologyDigestive system and related healthEpigenetics and DNA MethylationCancer Cells and Metastasis