Genetic variants associated with dengue hemorrhagic fever. A systematic review and meta-analysis
Mohammed Kanan, Mohammed Naffaa, Ahmed Z. Alanazi, Faiz Nasser, Ahad Amer Alsaiari, Mazen Almehmadi, Ali Assiry, Hisham M. A. Muzafar, Hejab Katam, A. Arar, Syed Mohammed Basheeruddin Asdaq, Abida, Mohd Imran, Tafadzwa Dzinamarira
Abstract
Dengue hemorrhagic fever (DHF) is a severe condition resulting from the dengue virus, with four serotypes known as DEN-1, DEN-2, DEN-3, and DEN-4. Genetic variations play a crucial role in influencing susceptibility to DHF. Therefore, this investigation conducted a meta-analysis to uncover genetic changes that might have remained undetected in individual studies due to small sample sizes or methodological differences. Among 2212 initially identified studies, 23 were deemed suitable for analysis based on PRISMA guidelines. Toll-like receptors (TLR) and CD209 showed significant association with DHF (odds ratios: TLR=0.56, CD209 =0.55), indicating protective effects. However, tumor necrosis factor (TNF) and human leukocyte antigen (HLA) did not exhibit a statistically significant relationship with DHF. This study emphasizes the relevance of TLR and CD209 in DHF susceptibility and resistance across diverse geographical locations.