Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents
Gangqiang Yang, Hao Xie, Conghui Wang, Chen Zhang, Liping Yu, Luyu Zhang, Xin Liu, Ruoxuan Xu, Zhihua Song, Rongxia Liu, Minoru Ueda
Topics & Concepts
ChemistryCyclin-dependent kinase 1LysosomeSubcellular localizationCyclin B1Cancer cellCell biologyCell growthAutophagyDownregulation and upregulationCyclinCyclin AKinaseCell cycleBiochemistryCancer researchCellCancerApoptosisBiologyCytoplasmEnzymeGeneticsGeneSynthesis and bioactivity of alkaloidsPhytochemical compounds biological activitiesBerberine and alkaloids research