Phenanthrenes from <i>Dendrobium senile</i> and their pancreatic lipase inhibitory activity
Myat Pann Phyu, Virunh Kongkatitham, Wanwimon Mekboonsonglarp, Kittisak Likhitwitayawuid, Boonchoo Sritularak
Abstract
From the whole plant of Dendrobium senile, a new phenanthrene namely 2,5,7-trihydroxy-4-methoxyphenanthrene (1) was isolated, together with seven known compounds including moscatin (2), 2,5-dihydroxy-4,9-dimethoxyphenanthrene (3), moscatilin (4), aloifol I (5), 4,4′,8,8′-tetramethoxy[1,1′-biphenanthrene]-2,2′,7,7′-tetrol (6), 2,2′,7,7′-tetrahydroxy-4,4′-dimethoxy-1,1′-biphenanthrene (7) and bleformin G (8). The structure of the new compound was elucidated by analysis of its spectroscopic data. Moscatin (2) and 2,5-dihydroxy-4,9-dimethoxyphenanthrene (3) showed appreciable pancreatic lipase inhibitory effects when compared with the positive control orlistat.