Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis
Runze Yang, Huo‐Liang Zheng, Wenning Xu, Xin‐Feng Zheng, Bo Li, Lei‐Sheng Jiang, Sheng‐Dan Jiang
Abstract
experiments, we demonstrated that exosomes derived from vascular endothelial cells decreased the ability of chondrocytes to resist oxidative stress by inhibiting autophagy and p21 expression, thereby increasing the cellular ROS content and inducing apoptosis. These findings indicate that exosomes derived from vascular endothelial cells promote the progression of OA, thus, providing new ideas for the diagnosis and treatment of OA.
Topics & Concepts
MicrovesiclesPathogenesisApoptosisOsteoarthritisChondrocyteCell biologyCellEndothelial stem cellMedicineCancer researchImmunologyChemistryBiologyCartilagePathologymicroRNAAnatomyGeneBiochemistryIn vitroAlternative medicineOsteoarthritis Treatment and MechanismsExtracellular vesicles in diseaseBone and Joint Diseases