Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis
Lucy O’Connor, Duong Van Anh, Tran Thi Hong Chau, Nguyễn Văn Vĩnh Châu, Lan Nguyễn Phú Hương, Marcel Wolbers, Jeremy Day
Abstract
We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.
Topics & Concepts
FlucytosineCryptococcal meningitisFluconazoleAmphotericin BMedicineAntifungalCryptococcosisCryptococcus neoformansMycosisMeningitisMicrobiologyInternal medicineImmunologyBiologyHuman immunodeficiency virus (HIV)SurgeryViral diseaseDermatologyFungal Infections and StudiesAntifungal resistance and susceptibilityNail Diseases and Treatments