<i>N</i> <sup>6</sup> -methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5
Jeffrey A. Purslow, Trang Nguyen, Balabhadra Khatiwada, Aayushi Singh, Vincenzo Venditti
Abstract
Our study reveals the molecular mechanisms underlying activation of Alkbh5, therefore opening new perspectives for the design of novel strategies to control gene expression and cancer progression.
Topics & Concepts
DemethylaseSubstrate (aquarium)RNAChemistrySelectivityCell biologyStereochemistryBiologyBiophysicsBiochemistryGeneEpigeneticsCatalysisEcologyRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms