Efficient synthesis and excellent antimicrobial activity of star-shaped cationic polypeptides with improved biocompatibility
Hao Liu, Xu Zhang, Ziyin Zhao, Fangping Yang, Ruizhong Xue, Lichen Yin, Ziyuan Song, Jianjun Cheng, Shifang Luan, Haoyu Tang
Abstract
Star poly(<sub>L</sub>-lysine) homo- and copolymers with excellent antimicrobial activity and improved biocompatibility can be readily prepared by the combination of ultra-fast ring opening polymerization and efficient side-chain modification.
Topics & Concepts
BiocompatibilityCationic polymerizationAntimicrobialCopolymerChemistryPolymerizationStar (game theory)Combinatorial chemistrySide chainRing-opening polymerizationPolymer chemistryPolymerOrganic chemistryPhysicsAstrophysicsAntimicrobial agents and applicationsAntimicrobial Peptides and ActivitiesPharmaceutical and Antibiotic Environmental Impacts