Click synthesis of some novel benzo[ <i>d</i> ]thiazole–1,2,3-triazole hybrid compounds with benzamide and/or benzoate tethers as EGFR-dependent signaling inhibitors against breast cancer
Mosa Alsehli, Mohamed S. Nafie, Nader R. Albujuq, Sanaa K. Bardaweel, Ateyatallah Aljuhani, Haytham O. Tawfik, Shaya Y. Al‐Raqa, Mohamed K. Diab, Nadjet Rezki, Mohamed Reda Aouad
Abstract
values of 4.98 μM, 0.21 μM, and 0.49 nM, respectively, compared to their reference inhibitors. Finally, a molecular docking study highlighted the binding mode disposition and binding interactions with key amino acids as a promising EGFR inhibitor.
Topics & Concepts
BenzamideThiazoleChemistryTriazoleClick chemistryBreast cancer1,2,3-TriazoleStereochemistryCombinatorial chemistryCancerOrganic chemistryMedicineInternal medicineClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic CompoundsMonoclonal and Polyclonal Antibodies Research