Small Noncoding RNA (sncRNA1) within the Latency-Associated Transcript Modulates Herpes Simplex Virus 1 Virulence and the Host Immune Response during Acute but Not Latent Infection
Kati Tormanen, Harry H. Matundan, Shaohui Wang, Ujjaldeep Jaggi, Kevin R. Mott, Homayon Ghiasi
Abstract
HSV-1 latency-associated transcript (LAT) plays a major role in establishing latency and reactivation; however, the mechanism by which LAT controls these processes is largely unknown. In this study, we sought to establish the role of the small noncoding RNA1 (sncRNA1) encoded within LAT during HSV-1 ocular infection. Our results suggest that sncRNA1 has a protective role during acute ocular infection by modulating the innate immune response to infection.
Topics & Concepts
BiologyHerpes simplex virusVirusVirologyVirus latencyViral replicationRNAGeneGeneticsHerpesvirus Infections and Treatmentsinterferon and immune responsesCancer-related molecular mechanisms research