HCMV Infection Reduces Nidogen-1 Expression, Contributing to Impaired Neural Rosette Development in Brain Organoids
Emmanuel C. Ijezie, John M. O’Dowd, Man I Kuan, Alexandra R. Faeth, Elizabeth A. Fortunato
Abstract
knockdown iPSCs recapitulated the structural defects observed in HCMV-infected rosettes. Findings in this study revealed HCMV infection induced early and dramatic structural changes in 3D brain organoids. We believe our results suggest a major role for infection-induced NID1 downregulation in HCMV-induced CNS birth defects.
Topics & Concepts
BiologyCentral nervous systemOrganoidFetusPathologicalImmunologyNervous systemNeuroscienceVirologyCell biologyPathologyPregnancyGeneticsMedicineCytomegalovirus and herpesvirus researchPolyomavirus and related diseasesRNA regulation and disease