Asymmetric Markovnikov Hydroaminocarbonylation of Alkenes Enabled by Palladium-Monodentate Phosphoramidite Catalysis
Ya‐Hong Yao, Huiyi Yang, Ming Chen, Fei Wu, Xingxing Xu, Zheng‐Hui Guan
Abstract
was discovered which exhibited very high reactivity and selectivity in the reaction. This asymmetric Markovnikov hydroaminocarbonylation employs readily available starting materials and tolerates a wide range of functional groups, thus providing a facile and straightforward method for the regio- and enantioselective synthesis of 2-substituted propanamides under ambient conditions. Mechanistic studies revealed that the reaction proceeds through a palladium hydride pathway.
Topics & Concepts
Markovnikov's ruleChemistryPhosphoramiditeStereocenterPalladiumEnantioselective synthesisCatalysisCombinatorial chemistrySelectivityDenticityAlkeneLigand (biochemistry)RegioselectivityOrganic chemistryCrystal structureBiochemistryOligonucleotideDNAReceptorCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis