Photocytotoxic kinetically stable ruthenium(<scp>ii</scp>)-<i>N</i>,<i>N</i>-donor polypyridyl complexes of oxalate with anticancer activity against HepG2 liver cancer cells
Juhi Sayala, Ekta Srivastava, Priyaranjan Kumar, Nitin Shukla, Ashok Kumar, Ashis K. Patra
Abstract
and effective interaction with DNA. All the complexes were internalized by the HepG2 liver cancer cells efficiently and localized to the cytoplasm and nucleus. The complexes exhibited potent anti-proliferative, anti-clonogenic, and anti-migratory effects on the cancer cells, suggesting their potential for therapeutic applications.
Topics & Concepts
OxalateRutheniumChemistryLiver cancerDNACancer cellCancerStereochemistryCombinatorial chemistryBiochemistryCatalysisInorganic chemistryBiologyGeneticsMetal complexes synthesis and propertiesPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry