Design, synthesis, and evaluation of “dual-site”-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase
Da Feng, Xiaofang Zuo, Lanlan Jing, Chin‐Ho Chen, Fisayo A. Olotu, Hao Lin, Mahmoud E. S. Soliman, Erik De Clercq, Christophe Pannecouque, Kuo‐Hsiung Lee, Dongwei Kang, Xinyong Liu, Peng Zhan
Topics & Concepts
ChemistryReverse transcriptaseHuman immunodeficiency virus (HIV)LentivirusReverse-transcriptase inhibitorBinding siteStereochemistryActive siteVirologyEnzymeBiochemistryViral diseaseRNAGeneBiologyHIV/AIDS drug development and treatmentHIV Research and TreatmentBiochemical and Molecular Research