Targeting BCL-2 proteins in pediatric cancer: Dual inhibition of BCL-XL and MCL-1 leads to rapid induction of intrinsic apoptosis
Sarah Kehr, Tinka Haydn, Annika Bierbrauer, Barnabas Irmer, Meike Vogler, Simone Fulda
Topics & Concepts
Bcl-xLApoptosisRhabdomyosarcomaPediatric cancerOsteosarcomaCancer researchChemistryBcl-2 familyIn vitroBiologyProgrammed cell deathCell biologySarcomaCancerBiochemistryMedicinePathologyGeneticsCell death mechanisms and regulationRNA Interference and Gene DeliveryCancer-related Molecular Pathways