Investigation of carbonic anhydrase inhibitory effects and cytotoxicities of pyrazole-based hybrids carrying hydrazone and zinc-binding benzenesulfonamide pharmacophores
Cem Yamalı, Hiroshi Sakagami, Keitaro Satoh, Kenjiro Bandow, Yoshihiro Uesawa, Silvia Bua, Andrea Angeli, Claudiu T. Supuran, Halise İnci Gül
Topics & Concepts
ChemistryPyrazoleCarbonic anhydrasePharmacophoreCytotoxicityIC50StereochemistryCell cultureHydrazoneCell growthEnzymeBiochemistryIn vitroGeneticsBiologyEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities