The toxin mimic FS48 from the salivary gland of Xenopsylla cheopis functions as a Kv1.3 channel-blocking immunomodulator of T cell activation
Qingye Zeng, Wancheng Lu, Zhenhui Deng, Bei Zhang, Jiena Wu, Jinwei Chai, Xin Chen, Xueqing Xu
Abstract
influx, MAPK/NF-κB/NFATc1 pathway activation, and TNF-α and IL-2 production in activated Jurkat T cells. Finally, we show that FS48 relieved the DTH response in rats. We therefore conclude that FS48 can block the Kv1.3 channel and inhibit human T cell activation, which most likely contributes to its immunomodulatory actions and highlights the great potential of this evolutionary-guided peptide as a drug template in future studies.
Topics & Concepts
Jurkat cellsProinflammatory cytokineSecretionCell biologyT cellBiologyMAPK/ERK pathwayCell cultureSignal transductionImmunologyImmune systemInflammationBiochemistryGeneticsIon channel regulation and functionNicotinic Acetylcholine Receptors StudyIon Channels and Receptors