An Efficient and Practical Construction of S−N Bond from Aryl Thioureas and Amines under Metal‐Free Conditions
Zhichao Hu, Yue‐Xiao Wu, Lei Ye, Jingjing Cui, Zhi‐Bing Dong
Abstract
Abstract An efficient and practical construction of S−N bond from aryl thioureas and amines under mild and metal‐free conditions is reported. A series of sulfenamides was obtained smoothly from aryl thioureas and amines (mainly secondary amines) through cross dehydrogenation coupling reaction (CDC) in the presence of phenyliodine(III) diacetate. The protocol features easily available starting materials, easy and odorless performance, mild reaction conditions, good yields, and a broad substrate scope, illustrating its synthetic value for the synthesis of diverse biologically or pharmaceutically relevant compounds.
Topics & Concepts
ChemistryArylDehydrogenationCombinatorial chemistrySubstrate (aquarium)Reaction conditionsOrganic chemistryScope (computer science)MetalCatalysisGeologyOceanographyProgramming languageAlkylComputer scienceSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsChemical Synthesis and Reactions