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Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells

Jie Liu, Ye Wan, Jiangping Xu, Haitao Wang, Xiaofang Li, Wenya Wang, Zhong‐Zhen Zhou

2021European Journal of Medicinal Chemistry17 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryGliomaTubulinApoptosisOxazoleLung cancerCancer cellStereochemistryCancer researchBiochemistryCancerCell biologyMicrotubuleBiologyInternal medicineMedicineGeneticsPhosphodiesterase function and regulationSynthesis and Catalytic ReactionsCholinesterase and Neurodegenerative Diseases
Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells | Litcius