Visible-Light-Mediated Late-Stage Sulfonylation of Anilines with Sulfonamides
Xiaohong Xu, Jing-Song Zhen, Xian Du, Yuan Han, Yihui Li, Man-Hei Chu, Yong Luo
Abstract
A visible-light-mediated late-stage sulfonylation of anilines with sulfonamides under simple reaction conditions is presented. Various primary or secondary sulfonamides including several pharmaceuticals were incorporated successfully via N-S bond activation and C-H bond sulfonylation. The synthetic utility of this strategy is highlighted by the construction of complex anilines bearing diverse bioactive groups.
Topics & Concepts
ChemistrySulfonamidePrimary (astronomy)Combinatorial chemistryOrganic chemistryPhysicsAstronomySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsChemical Synthesis and Reactions