Inside Cover: Engineered Histidine‐Rich Peptides Enhance Endosomal Escape for Antibody‐Targeted Intracellular Delivery of Functional Proteins (Angew. Chem. Int. Ed. 38/2023)
Yan Zhao, Haolin Jiang, Jiazhen Yu, Luyao Wang, Juanjuan Du
Abstract
A histidine-rich endosomal escape peptide, as described by Juanjuan Du et al. in their Research Article (e202304692), is capable of mediating efficient endosome-to-cytosol transport of peptide/protein cargo, depicted in the cover picture as butterflies escaping from bubbles trapping them. Once combined with antibody-mediated endocytosis, this strategy enables cell-specific cytosolic delivery of functional proteins.
Topics & Concepts
EndosomeEndocytosisCytosolPeptideIntracellularHistidineChemistryCell biologyTransport proteinBiophysicsBiochemistryCellBiologyAmino acidEnzymeRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesSupramolecular Self-Assembly in Materials