Enhanced stability of complex coacervate core micelles following different core-crosslinking strategies
Riahna Kembaren, J. Mieke Kleijn, Jan Willem Borst, Marleen Kamperman, Anton H. Hofman
Abstract
, QP2VP). For these two strategies we used the crosslinkers 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and dimethyl-3,3'-dithiopropionimidate dihydrochloride (DTBP), respectively. EDC provides permanent crosslinks, while DTBP crosslinks can be broken by a reducing agent. Dynamic light scattering showed that both approaches significantly improved the stability of C3Ms against salt and pH changes. Furthermore, reduction of the disulphide bridges in the DTBP core-crosslinked micelles largely restored the original salt-stability profile. Therefore, this feature provides an excellent starting point for the application of C3Ms in controlled release formulations.