Bovine milk-derived extracellular vesicles prevent gut inflammation by regulating lipid and amino acid metabolism
Chunmei Du, Suyu Quan, Yiguang Zhao, Xuemei Nan, Ruipeng Chen, Xiangfang Tang, Benhai Xiong
Abstract
-11-eicosenoic acid (C20:1). Moreover, the concentrations of eicosadienoic acid (C20:2), eicosapentaenoic acid (C20:5), and docosahexaenoic acid (C22:6) were decreased in colonic tissues with mEV supplementation. In addition, compared with the DSS group, mEVs significantly increased the content of L-arginine, decreased the level of L-valine in the fecal samples, and also decreased the levels of L-serine and L-glutamate in the colonic tissues. Collectively, our findings demonstrated that mEVs could recover the metabolic abnormalities caused by inflammation and provided novel insights into mEVs as a potential modulator for metabolites to prevent and treat IBD.