20(<i>S</i>)-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9
Yewei Huang, Meng Zhang, Litian Wang, Yan Nie, Jinbo Yang, WenLuer Meng, Xuanjun Wang, Jun Sheng
Abstract
saponins in the intestinal tract, can bind to the extracellular domain of LDLR and inhibit the role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in mediating LDLR degradation. The results showed that PPD significantly reduced aortic plaques and hepatic steatosis in HFD-fed ApoE KO mice. LDLR protein levels were elevated in the liver tissues isolated from PPD-treated HFD-fed ApoE KO mice and PPD-treated HepG2 cells. Our findings demonstrated that PPD significantly increased LDLR levels and reduced AS in the HFD-fed ApoE KO mice on account of LDLR degradation being inhibited by PPD inhibiting the interaction between PCSK9 and LDLR.
Topics & Concepts
LDL receptorPCSK9ChemistryExtracellularInternal medicineApolipoprotein EEndocrinologyReceptorCholesterolBiologyMedicineBiochemistryLipoproteinDiseaseGinseng Biological Effects and ApplicationsLipid metabolism and disordersAtherosclerosis and Cardiovascular Diseases