Characterization of T lymphocytes in severe COVID‐19 patients
Daniela Fenoglio, Chiara Dentone, Alessia Parodi, Antonio Di Biagio, Federica Bozzano, Antonio Vena, Marina Fabbi, Francesca Ferrera, Tiziana Altosole, Bianca Bruzzone, Mauro Giacomini, Paolo Pelosi, Andrea De Maria, Matteo Bassetti, Raffaele De Palma, Gilberto Filaci
Abstract
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
Topics & Concepts
VirologyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakBiologyMedicineOutbreakPathologyDiseaseInfectious disease (medical specialty)COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19SARS-CoV-2 and COVID-19 Research